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Don’t mix business with pleasure. Alprazolam is not to be taken with ketoconazole (Nizoral) or itraconazole (Sporanox) without first talking to your doctor.

Alprazolam may increase the effects of other medications that cause drowsiness, such as antidepressants, , antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, muscle relaxants and alcohol.

Inform your doctor about all medicines you are currently taking, and do not take any drug without first talking to your doctor. The effects of alprazolam may be decresed by antacids.

In such cases, separate doses of an antacid and alprazolam by several hours whenever it is possible.

Medications other than those listed here may also interact with alprazolam. Talk to your doctor before taking any prescription or over-the-counter medicines (including herbal products).